Fannie Mae and Freddie Mac issued $45.4 billion in single-family mortgage-backed securities during the month of April, a 20.6 percent increase from March, reversing more than a year-long streak of declines, according to an Inside The GSEs analysis. However, April’s MBS issuance was down 63.0 percent from the same period a year ago.Top-ranked Wells Fargo’s Fannie and Freddie securitization, at $6.28 billion, rose by 23.1 percent on a monthly basis but dropped 73.3 percent year-to-date.